Deep Vein Thrombosis (DVT) is a chronic condition with high risk of occurrence among Elderly and pregnant women as well as in many others due to medical or lifestyle related conditions such as Cancer, Diabetes, Obesity, long-haul flight. DVT can cause Pulmonary Embolism (PE) which often results into death. The computational investigation could help doctors and primary care physicians by better understanding the physics involved in the clot formation and its movement through the veins. (Collaborators: Drs. Herb Jansen - Texas Tech Medical Center, Victor Udeowa - AAAS Fellow)
- U. Parimi*, V. Kumar, H. F. Jansen, V. Udoewa: Fluid Analysis of the Deep Veins to Analyze the Chances of Formation of a Deep Vein Thrombosis (DVT), ASME, 5th Frontiers in Biomedical Devices - BioMed2010-32071 (2010)- Upendra Parimi, M.S., COMPUTATIONAL STUDY OF FLUID-VALVE INTERACTION INVOLVING DEEP VEIN THROMBOSIS , Mechanical Engineering, University of Texas at El Paso (Dec 2010)Embedded Files
Numerical investigation of the collagen & cardiomyocytes
Collagen is found as a mixture of type I and type III collagen within the extracellular matrix (ECM) of myocardial tissue, and forms an integral part of cardiac cellular structure. Following myocardial infarction, this mixture is altered with an increase of type I collagen production, leading to the stiffening of the heart. Extracellular forces on cardiomyocytes as a result of an upregulation of type I collagen may be the key to understanding the true effect of an altered collagen I:III ratio post infarction. We use CFD M&S to understanding the mechanical forces that are at play to understand their role in altering cardiomyocyte morphology. (Collaborator: Dr. Joddar, Biomedical Engineering, UTEP)
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